Publications 2022
Balzano G, Zerbi A, Aleotti F, Capretti G, Melzi R, Pecorelli N, Mercalli A, Nano R, Magistretti P, Gavazzi F, De Cobelli F, Poretti D, Scavini M, Molinari C, Partelli S, Crippa S, Maffi P, Falconi M, Piemonti L
Total Pancreatectomy with islet Autotransplantation as an Alternative to high-risk Pancreatojejunostomy after Pancreaticoduodenectomy: A Prospective Randomized Trial
Ann Surg. 2022 Sep 30. doi: 10.1097/SLA.0000000000005713.
Visser MM, Charleer S, Fieuws S, De Block C, Hilbrands R, Van Huffel L, Maes T, Vanhaverbeke G, Dirinck E, Myngheer N, Vercammen C, Nobels F, Keymeulen B, Mathieu C, Gillard P
The Impact of Baseline User Characteristics on the Benefits of Real-Time Versus Intermittently Scanned Continuous Glucose Monitoring in Adults With Type 1 Diabetes: Moderator Analyses of the ALERTT1 Trial
J Diabetes Sci Technol. 2022 Sep 29;19322968221128315. doi: 10.1177/19322968221128315.
Piemonti L, Keymeulen B, Gillard P, Linn T, Bosi E, Rose L, Pozzilli P, Giorgino F, Cossu E, Daffonchio L, Goisis G, Ruffini PA, Maurizi AR, Mantelli F, Allegretti M
Ladarixin, an inhibitor of the interleukin-8 receptors CXCR1 and CXCR2, in new-onset type 1 diabetes: A multicentre, randomized, double-blind, placebo-controlled trial
Diabetes Obes Metab. 2022 Sep;24(9):1840-1849. doi: 10.1111/dom.14770. Epub 2022 Jul 4.
Pellegrini S, Zamarian V, Cospito ELA, Lombardo MT, Manenti F, Citro A, Schiavo Lena M, Piemonti L, Sordi V
Treating iPSC-Derived β Cells with an Anti-CD30 Antibody-Drug Conjugate Eliminates the Risk of Teratoma Development upon Transplantation
Int J Mol Sci. 2022 Aug 26;23(17):9699. doi: 10.3390/ijms23179699.
Pignatelli C, Campo F, Neroni A, Piemonti L, Citro A
Bioengineering the Vascularized Endocrine Pancreas: A Fine-Tuned Interplay Between Vascularization, Extracellular-Matrix-Based Scaffold Architecture, and Insulin-Producing Cells
Transpl Int. 2022 Aug 25;35:10555. doi: 10.3389/ti.2022.10555. eCollection 2022.
Wyatt RC, Hagopian WA, Roep BO, Patel KA, Resnick B, Dobbs R, Hudson M, EXE-T1D Consortium; De Franco E, Ellard S, Flanagan SE, Hattersley AT, Oram RA, Johnson MB
Congenital beta cell defects are not associated with markers of islet autoimmunity, even in the context of high genetic risk for type 1 diabetes
Diabetologia. 2022 Jul;65(7):1179-1184. doi: 10.1007/s00125-022-05697-3. Epub 2022 Apr 30.
den Hollander NHM, Roep BO
From Disease and Patient Heterogeneity to Precision Medicine in Type 1 Diabetes
Front Med (Lausanne). 2022 Jul 12;9:932086. doi: 10.3389/fmed.2022.932086. eCollection 2022.
De Paep DL, Van Hulle F, Ling Z, Vanhoeij M, Hilbrands R, Distelmans W, Gillard P, Keymeulen B, Pipeleers D, Jacobs-Tulleneers-Thevissen D
Utility of Islet Cell Preparations From Donor Pancreases After Euthanasia
Cell Transplant. 2022 Jan-Dec;31:9636897221096160. doi: 10.1177/09636897221096160
Gootjes C, Zwaginga JJ, Roep BO, Nikolic T
Functional Impact of Risk Gene Variants on the Autoimmune Responses in Type 1 Diabetes
Front Immunol. 2022 May 4;13:886736. doi: 10.3389/fimmu.2022.886736. eCollection 2022.
Van Hulle F, De Groot K, Hilbrands R, Van de Velde U, Suenens K, Stangé G, De Mesmaeker I, De Paep DL, Ling Z, Roep BO, Gillard P, Pipeleers D, Keymeulen B, Jacobs-Tulleneers-Thevissen D
Function and composition of pancreatic islet cell implants in omentum of type 1 diabetes patients
Am J Transplant. 2022 Mar;22(3):927-936. doi: 10.1111/ajt.16884. Epub 2021 Nov 16.
El Malahi A, Van Elsen M, Charleer S, Dirinck E, Ledeganck K, Keymeulen B, Crenier L, Radermecker R, Taes Y, Vercammen C, Nobels F, Mathieu C, Gillard P, De Block C
Relationship Between Time in Range, Glycemic Variability, HbA1c, and Complications in Adults With Type 1 Diabetes Mellitus
J Clin Endocrinol Metab. 2022 Jan 18;107(2):e570-e581. doi: 10.1210/clinem/dgab688.
Publications 2021
Shapiro AMJ, Thompson D, Donner TW, Bellin MD, Hsueh W, Pettus J, Wilensky J, Daniels M, Wang RM, Brandon EP, Jaiman MS, Kroon EJ, D’Amour KA, Foyt HL
Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device
Cell Rep Med. 2021 Dec 2;2(12):100466. doi: 10.1016/j.xcrm.2021.100466. eCollection 2021 Dec 21.
Oh E, McCown EM, Ahn M, Garcia PA, Branciamore S, Tang S, Zeng DF, Roep BO, Thurmond DC
Syntaxin 4 Enrichment in β-Cells Prevents Conversion to Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice
Diabetes. 2021 Dec;70(12):2837-2849.doi: 10.2337/db21-0170. Epub 2021 Sep 23.
Anderson AM, Landry LG, Aimon A Alkanani, Pyle L, Powers AC, Atkinson MA, Mathews CE, Roep BO, Michels AW, Nakayama M
Human islet T cells are highly reactive to preproinsulin in type 1 diabetes
Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):e2107208118.doi: 10.1073/pnas.2107208118.
Thomaidou S, Slieker RC, van der Slik AR, Boom J, Mulder F, Munoz-Garcia A, ‘t Hart LM, Koeleman B, Carlotti F, Hoeben RC, Roep BO, Mei H, Zaldumbide A
Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape
Diabetes. 2021 Oct;70(10):2299-2312.doi: 10.2337/db20-1122. Epub 2021 Jun 15.
Roep BO, Montero E, van Tienhoven R, Atkinson MA, Schatz DA, Mathieu C
Defining a cure for type 1 diabetes: a call to action
Lancet Diabetes Endocrinol. 2021 Sep;9(9):553-555.doi: 10.1016/S2213-8587(21)00181-9. Epub 2021 Jul 30.
Vandewalle J, Van der Auwera BJ, Amin H, Quartier E, Desouter AK, Tenoutasse S, Gillard P, De Block C, Keymeulen B, Gorus FK, Van de Casteele M, Belgian Diabetes Registry
Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope spreading in single autoantibody-positive relatives
Diabetologia. 2021 Nov;64(11):2511-2516. doi: 10.1007/s00125-021-05546-9. Epub 2021 Aug 26.
Smeets S, De Paep DL, Stangé G, Verhaeghen K, Van der Auwera B, Keymeulen B, Weets I, Ling Z, In’t Veld P, Gorus F
Insulitis in the pancreas of non-diabetic organ donors under age 25 years with multiple circulating autoantibodies against islet cell antigens
Virchows Arch. 2021 Aug;479(2):295-304.doi: 10.1007/s00428-021-03055-z. Epub 2021 Feb 16.
Erdem N, Montero E, Roep BO
Breaking and restoring immune tolerance to pancreatic beta-cells in type 1 diabetes
Curr Opin Endocrinol Diabetes Obes. 2021 Aug 1;28(4):397-403.
Martens GA, Stangé G, Piemonti L, Anckaert J, Ling Z, Pipeleers D, Gorus FK, Mestdagh P, De Smet D, Vandesompele J, Keymeulen B, Roels S
The MicroRNA Landscape of Acute Beta Cell Destruction in Type 1 Diabetic Recipients of Intraportal Islet Grafts
Cells. 2021 Jul 4;10(7):1693.doi: 10.3390/cells10071693.
De Paep DL, Van Hulle F, Ling Z, Vanhoeij M, Pirenne J, Keymeulen B, Pipeleers D, Jacobs-Tulleneers-Thevissen D
Lower beta cell yield from donor pancreases after controlled circulatory death prevented by shortening acirculatory warm ischemia time and by using IGL-1 cold preservation solution
PLoS One. 2021 May 3;16(5):e0251055.doi: 10.1371/journal.pone.0251055. eCollection 2021.
Akerman I, Maestro MA, De Franco E, Grau V, Flanagan S, García-Hurtado J, Mittler G, Ravassard P, Piemonti L, Ellard S, Hattersley AT, Ferrer J
Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene
Cell Rep. 2021 Apr 13;35(2):108981.doi: 10.1016/j.celrep.2021.108981.
Zirpel H, Roep BO
Islet-Resident Dendritic Cells and Macrophages in Type 1 Diabetes: In Search of Bigfoot’s Print
Front Endocrinol (Lausanne). 2021 Apr 12;12:666795.doi: 10.3389/fendo.2021.666795. eCollection 2021.
Gesmundo I, Pardini B, Gargantini E, Gamba G , Birolo G, Fanciulli A, Banfi D, Congiusta N, Favaro E, Deregibus MC, Togliatto G, Zocaro G, Brizzi MF, Luque RM, Castaño JP, Bocchiotti MA, Arolfo S, Bruno S, Nano R, Morino M, Piemonti L, Ong H, Matullo G, Falcón-Pérez JM, Ghigo E, Camussi G, Granata R
Adipocyte-derived extracellular vesicles regulate survival and function of pancreatic β cells
JCI Insight. 2021 Mar 8;6(5):e141962.doi: 10.1172/jci.insight.141962.
Keymeulen B, van Maurik A, Inman D, Oliveira J, McLaughlin R, Gittelman RM, Roep BO, Gillard P, Hilbrands R, Gorus F, Mathieu C, Van de Velde U, Wisniacki N, Napolitano A
A randomised, single-blind, placebo-controlled, dose-finding safety and tolerability study of the anti-CD3 monoclonal antibody otelixizumab in new-onset type 1 diabetes
Diabetologia. 2021 Feb;64(2):313-324.doi: 10.1007/s00125-020-05317-y. Epub 2020 Nov 4.
Citro A, Campo F, Dugnani E, Piemonti L
Innate Immunity Mediated Inflammation and Beta Cell Function: Neighbors or Enemies?
Front Endocrinol (Lausanne). 2021 Feb 8;11:606332.doi: 10.3389/fendo.2020.606332. eCollection 2020.
Nasteska D, Fine NHF, Ashford FB, Cuozzo F, Viloria K, Smith G, Dahir A, Dawson PWJ, Lai YC, Bastidas-Ponce A, Bakhti M, Rutter GA, Fiancette R, Nano R, Piemonti L, Lickert H, Zhou Q, Akerman I, Hodson DJ
PDX1 LOW MAFA LOW β-cells contribute to islet function and insulin release
Nat Commun. 2021 Jan 29;12(1):674.doi: 10.1038/s41467-020-20632-z.
Bolla AM, Gandolfi A, Borgonovo E, Laurenzi A, Caretto A, Molinari C, Catalano RS, Bianconi E, Monti P, Sordi V, Pellegrini S, Lampasona V, Costa S, Scavini M, Bosi E, Piemonti L.
Rapamycin Plus Vildagliptin to Recover β-Cell Function in Long-Standing Type 1 Diabetes: A Double-Blind, Randomized Trial.
J Clin Endocrinol Metab. 2021 Jan 23;106(2):e507-e519.doi: 10.1210/clinem/dgaa791.
Pellegrini S, Pipitone GB, Cospito A, Manenti F, Poggi G, Lombardo MT, Nano R, Martino G, Ferrari M, Carrera P, Sordi V, Piemonti L.
Generation of β cells from iPSC of a MODY8 patient with a novel mutation in the carboxyl ester lipase (CEL) gene.
J Clin Endocrinol Metab. 2021 Jan 8;dgaa986.doi: 10.1210/clinem/dgaa986.
Publications 2020
De Paep DL, Gillard P, Ling Z, Verbeke H, Maleux G, Vandecaveye V, Debaveye Y, Keymeulen B, van der Merwe S, Pipeleers DG, Pirenne J, van Malenstein H, Jacobs-Tulleneers-Thevissen D.
Use of hyperglycemic clamp to assess pancreatectomy and islet cell autotransplant in patient with heterotaxy syndrome and dorsal pancreas agenesis leading to chronic pancreatitis.
Am J Transplant. 2020 Dec;20(12):3662-3666.doi: 10.1111/ajt.16084.
Roep BO, Thomaidou S, van Tienhoven R, Zaldumbide A.
Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)
Nat Rev Endocrinol. 2020 Dec 8;1-12.doi: 10.1038/s41574-020-00443-4.
Pellegrini S, Chimienti R, Scotti GM, Giannese F, Lazarevic D, Manenti F, Poggi G, Lombardo MT, Cospito A, Nano R, Piemonti L, Sordi V.
Transcriptional dynamics of induced pluripotent stem cell differentiation into β cells reveals full endodermal commitment and homology with human islets.
Cytotherapy. 2020 Nov 24;S1465-3249(20)30929-4.doi: 10.1016/j.jcyt.2020.10.004.
Van Hulle F, De Groot K, Stangé G, Suenens K, De Mesmaeker I, De Paep DL, Ling Z , Hilbrands R , Gillard P, Keymeulen B, Kroon E, Westermark GT, Jacobs-Tulleneers-Thevissen D , Pipeleers DG.
Formation of amyloid in encapsulated human pancreatic and human stem cell-generated beta cell implants.
Am J Transplant. 2020 Nov 18. doi: 10.1111/ajt.16398.
Lee D, Gillard P, Hilbrands R, Ling Z, Van de Velde U, Jacobs-Tulleneers-Thevissen D, Maleux G, Lapauw B, Crenier L, De Block C, Mathieu C, Pipeleers D, Keymeulen B.
Use of Culture to Reach Metabolically Adequate Beta-cell Dose by Combining Donor Islet Cell Isolates for Transplantation in Type 1 Diabetes Patients.
Transplantation. 2020 Oct. doi: 10.1097/TP.0000000000003321.
Nikolic T, Zwaginga JJ, Uitbeijerse BS, Woittiez NJ, de Koning EJ, Aanstoot H, Roep BO.
Safety and feasibility of intradermal injection with tolerogenic dendritic cells pulsed with proinsulin peptide-for type 1 diabetes.
Lancet Diabetes Endocrinol. 2020 Jun;8(6):470-472.doi: 10.1016/S2213-8587(20)30104-2.
Maffi P, Lundgren T, Tufveson G, Rafael E,Shaw JAM, Liew A, Saudek F, Witkowski P, Golab K, Bertuzzi F, Gustafsson B, Daffonchio L, Ruffini PA, Piemonti L, REP0211 Study Group.
Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes.
Diabetes Care. 2020 Apr;43(4):710-718.doi: 10.2337/dc19-1480.
Smeets S, Stangé G, Leuckx G, Roelants L, Cools W, De Paep DL, Ling Z, De Leu N, In’t Veld P.
Evidence of Tissue Repair in Human Donor Pancreas After Prolonged Duration of Stay in Intensive Care.
Diabetes. 2020 Mar;69(3):401-412.doi: 10.2337/db19-0529.
Claessens LA, Wesselius J, van Lummel M, Laban S, Mulder F, Mul D, Nikolic T, Aanstoot HJ, Koeleman BPC, Roep BO.
Clinical and genetic correlates of islet-autoimmune signatures in juvenile-onset type 1 diabetes.
Diabetologia. 2020 Feb;63(2):351-361. doi: 10.1007/s00125-019-05032-3.
Suwandi JS, Laban S, Vass K,Joosten A, van Unen V, Lelieveldt BPF, Höllt T, Zwaginga JJ, Nikolic T, Roep BO.
Multidimensional analyses of proinsulin peptide-specific regulatory T cells induced by tolerogenic dendritic cells.
J Autoimmun. 2020 Feb;107:102361.doi: 10.1016/j.jaut.2019.102361.
Nano R, Kerr-Conte JA, Scholz H, Engelse M, Karlsson M, Saudek F, Bosco D, Antonioli B, Bertuzzi F, Johnson PRV, Ludwing B, Ling Z, De Paep DL, Keymeulen B, Pattou F, Berney T, Korsgren O, de Koning E, Piemonti L.
Heterogeneity of human pancreatic islet isolation around Europe: results of a survey study.
Transplantation. 2020 Jan 10. doi: 10.1097/TP.0000000000002777.
de Groot PF, Nikolic T, Imangaliyev S, Bekkering S, Duinkerken G, Keij FM, Herrema H, Winkelmeijer M, Kroon J, Levin E, Hutten B, Kemper EM, Simsek S, Levels JHM, van Hoorn FA, Bindraban R, Berkvens A, Dallinga-Thie GM, Davids M, Holleman F, Hoekstra JBL, Stroes ESG, Netea M, van Raalte DH, Roep BO, Nieuwdorp M.
Oral butyrate does not affect innate immunity and islet autoimmunity in individuals with longstanding type 1 diabetes: a randomised controlled trial.
Diabetologia. 2020 Jan 8. doi: 10.1007/s00125-019-05073-8.
Publications 2019
Roep BO.
A viral link for type 1 diabetes.
Nat Med. 2019 Dec;25(12):1816-1818. doi: 10.1038/s41591-019-0689-7.
van Megen KM, van ‘t Wout ET, Lages Motta J, Dekker B, Nikolic T, Roep BO.
Activated Mesenchymal Stromal Cells Process and Present Antigens Regulating Adaptive Immunity.
Front Immunol. 2019 Apr 3;10:694. doi:10.3389/fimmu.2019.00694.
van Lummel M, Buis DTP, Ringeling C, de Ru AH, Pool J, Papadopoulos GK, van Veelen PA, Reijonen H, Drijfhout JW, Roep BO.
Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 Diabetes.
Diabetes. 2019 Apr;68(4):787-795. doi: 10.2337/db18-0501.
Roep BO, Wheeler DCS, Peakman M.
Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine.
Lancet Diabetes Endocrinol. 2019 Jan;7(1):65-74. doi: 10.1016/S2213-8587(18)30109-8.
Vlasakakis G, Napolitano A, Barnard R, Brown K, Bullman J, Inman D, Keymeulen B, Lanham D, Leirens Q, MacDonald A, Mezzalana E, Page K, Patel M, Savage CO, Zamuner S, van Maurik A.
Target engagement and cellular fate of otelixizumab: a repeat dose escalation study of an anti-CD3ε mAb in new-onset type 1 diabetes mellitus patients.
Br J Clin Pharmacol. 2019 Apr;85(4):704-714. doi: 10.1111/bcp.13842.
Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A,Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U,Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG,Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D’Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A.
Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.
Transplantation.2018 Aug;102(8):1223-1229. doi: 10.1097/TP.0000000000002217. Review.
Gelin P, Sukas O, Hellemans K, Maes D, De Malsche W
Study on the mixing and migration behavior of micron-size particles in acoustofluidics.
Chem. Eng. Journal, DOI: 10.1016/j.cej.2019.03.004
Robert T, De Mesmaeker I, Van Hulle FO, Suenens KG, Stangé GM, Ling Z, Haller C, Bouche N, Keymeulen B, Kraus MRC, Pipeleers DG.
Cell Mass Increase Associated with Formation of Glucose-Controlling β-Cell Mass in Device-Encapsulated Implants of hiPS-Derived Pancreatic Endoderm.
Stem Cells Transl Med. 2019 Dec 4. doi: 10.1002/sctm.19-0043.
Akbib S, Stichelmans J, Stangé G, Ling Z, Assefa Z, Hellemans KH.
Glucocorticoids and checkpoint tyrosine kinase inhibitors stimulate rat pancreatic beta cell proliferation differentially.
PLoS One. 2019 Feb 19;14(2):e0212210. doi: 10.1371/journal.pone.0212210.
Roels S, Costa OR, Tersey SA, Stangé G, De Smet D, Balti EV, Gillard P, Keymeulen B, Ling Z, Pipeleers DG, Gorus FK, Mirmira RG, Martens GA.
Combined Analysis of GAD65, miR-375, and Unmethylated Insulin DNA Following Islet Transplantation in Patients With T1D.
J Clin Endocrinol Metab. 2019 Feb 1;104(2):451-460. doi: 10.1210/jc.2017-02520.
Di Dedda C, Vignali D, Piemonti L, Monti P.
Pharmacological Targeting of GLUT1 to Control Autoreactive T Cell Responses.
Int J Mol Sci. 2019 Oct 8;20(19). pii: E4962. doi: 10.3390/ijms20194962. Review.
Pellegrini S, Cantarelli E, Citro A, Incerti E, Piemonti L, Sordi V.
Selective local irradiation improves islet engraftment and survival in intra-bone marrow islet transplantation.
Cytotherapy. 2019 Oct;21(10):1025-1032. doi: 10.1016/j.jcyt.2019.07.005.
Nano R, Kerr-Conte JA, Bosco D, Karlsson M, Lavallard V, Melzi R, Gmyr V, Mercalli A, Berney T, Pattou F, Korsgren O, Piemonti L.
Islets for Research: Nothing Is Perfect, but We Can Do Better.
Diabetes. 2019 Aug;68(8):1541-1543.doi: 10.2337/db19-0367.
Citro A, Pellegrini S, Dugnani E, Eulberg D, Klussmann S, Piemonti L.
CCL2/MCP-1 and CXCL12/SDF-1 blockade by L-aptamers improve pancreatic islet engraftment and survival in mouse.
Am J Transplant. 2019 Jul 3. doi: 10.1111/ajt.15518.
Citro A, Moser PT, Dugnani E, Rajab TK, Ren X, Evangelista-Leite D, Charest JM, Peloso A, Podesser BK, Manenti F, Pellegrini S, Piemonti L, Ott HC.
Biofabrication of a vascularized islet organ for type 1 diabetes.
Biomaterials. 2019 Apr;199:40-51. doi: 10.1016/j.biomaterials.2019.01.035.
Balzano G, Maffi P, Nano R, Mercalli A, Melzi R, Aleotti F, De Cobelli F, Magistretti P, Scavini M, Secchi A, Falconi M, Piemonti L.
Diabetes-free survival after extended distal pancreatectomy and islet auto transplantation for benign or borderline/malignant lesions of the pancreas.
Am J Transplant. 2019 Mar;19(3):920-928. doi: 10.1111/ajt.15219. Epub 2019 Jan 23.
Publications 2018
Haller C, Chaskar P, Piccand J, Cominetti O, Macron C, Dayon L, Kraus MR.
Insights into Islet Differentiation and Maturation through Proteomic Characterization of a Human iPSC-Derived Pancreatic Endocrine Model.
Proteomics Clin Appl. 2018 Sep;12(5):e1600173. doi: 10.1002/prca.201600173. Epub 2018 May 4.
Balke EM, Balti EV, Van der Auwera B, Weets I, Costa O, Demeester S, Abrams P, Casteels K, Coeckelberghs M, Tenoutasse S, Keymeulen B, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.
Accelerated Progression to Type 1 Diabetes in the Presence of HLA-A*24 and -B*18 Is Restricted to Multiple Islet Autoantibody-Positive Individuals With Distinct HLA-DQ and Autoantibody Risk Profiles.
Diabetes Care. 2018 May;41(5):1076-1083. doi: 10.2337/dc17-2462.
Balke EM, Demeester S, Lee D, Gillard P, Hilbrands R, Van de Velde U, Van der Auwera BJ, Ling Z, Roep BO, Pipeleers DG, Keymeulen B, Gorus FK.
SLC30A8 polymorphism and BMI complement HLA-A*24 as risk factors for poor graft function in islet allograft recipients.
Diabetologia. 2018 Jul;61(7):1623-1632. doi: 10.1007/s00125-018-4609-z.
Cito M, Pellegrini S, Piemonti L, Sordi V.
The potential and challenges of alternative sources of β cells for the cure of type 1 diabetes.
Endocr Connect. 2018 Mar;7(3):R114-R125. doi: 10.1530/EC-18-0012. Review.
Citro A, Cantarelli E, Pellegrini S, Dugnani E, Piemonti L.
Anti-Inflammatory Strategies in Intrahepatic Islet Transplantation: A Comparative Study in Preclinical Models.
Transplantation. 2018 Feb;102(2):240-248. doi: 10.1097/TP.0000000000001925.
Costa OR, Verhaeghen K, Roels S, Stangé G, Ling Z, Pipeleers D, Gorus FK, Martens GA.
An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65.
PLoS One. 2018 Mar 8;13(3):e0193670. doi: 10.1371/journal.pone.0193670.
De Mesmaeker I, Robert T, Suenens KG, Stangé GM, Van Hulle F, Ling Z, Tomme P, Jacobs-Tulleneers-Thevissen D, Keymeulen B, Pipeleers DG.
Increase Functional β-Cell Mass in Subcutaneous Alginate Capsules With Porcine Prenatal Islet Cells but Loss With Human Adult Islet Cells.
Diabetes. 2018 Dec;67(12):2640-2649. doi: 10.2337/db18-0709.
Pellegrini S, Manenti F, Chimienti R, Nano R, Ottoboni L, Ruffini F, Martino G, Ravassard P, Piemonti L, Sordi V.
Differentiation of Sendai Virus-Reprogrammed iPSC into β Cells, Compared with Human Pancreatic Islets and Immortalized β Cell Line.
Cell Transplant. 2018 Oct;27(10):1548-1560. doi: 10.1177/0963689718798564.
Pellegrini S, Piemonti L, Sordi V.
Pluripotent stem cell replacement approaches to treat type 1 diabetes.
Curr Opin Pharmacol. 2018 Dec;43:20-26. doi: 10.1016/j.coph.2018.07.007.
Robert T, De Mesmaeker I, Stangé GM, Suenens KG, Ling Z, Kroon EJ, Pipeleers DG.
Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control.
Stem Cell Reports. 2018 Mar 13;10(3):739-750. doi: 10.1016/j.stemcr.2018.01.040.
Publications 2017
Cantarelli E, Citro A, Pellegrini S, Mercalli A, Melzi R, Dugnani E, Jofra T, Fousteri G, Mondino A, Piemonti L.
Transplant Site Influences the Immune Response After Islet Transplantation: Bone Marrow Versus Liver.
Transplantation. 2017 May;101(5):1046-1055. doi: 10.1097/TP.0000000000001462.
Gorus FK, Balti EV, Messaaoui A, Demeester S, Van Dalem A, Costa O, Dorchy H, Mathieu C, Van Gaal L, Keymeulen B, Pipeleers DG, Weets I; Belgian Diabetes Registry.
Twenty-Year Progression Rate to Clinical Onset According to Autoantibody Profile, Age, and HLA-DQ Genotype in a Registry-Based Group of Children and Adults With a First-Degree Relative With Type 1 Diabetes.
Diabetes Care. 2017 Aug;40(8):1065-1072. doi: 10.2337/dc16-2228.
Kracht MJ, van Lummel M, Nikolic T, Joosten AM, Laban S, van der Slik AR, van Veelen PA, Carlotti F, de Koning EJ, Hoeben RC, Zaldumbide A, Roep BO.
Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes.
Nat Med. 2017 Apr;23(4):501-507. doi: 10.1038/nm.4289.
Lee D, Keymeulen B, Hilbrands R, Ling Z, Van de Velde U, Jacobs-Tulleneers-Thevissen D, Maleux G, Lapauw B, Crenier L, De Block C, Mathieu C, Pipeleers D, Gillard P.
Age and Early Graft Function Relate With Risk-Benefit Ratio of Allogenic Islet Transplantation Under Antithymocyte Globulin-Mycophenolate Mofetil-Tacrolimus Immune Suppression.
Transplantation. 2017 Sep;101(9):2218-2227. doi: 10.1097/TP.0000000000001543.
Pipeleers D, De Mesmaeker I, Robert T, Van Hulle F.
Heterogeneity in the Beta-Cell Population: a Guided Search Into Its Significance in Pancreas and in Implants.
Curr Diab Rep. 2017 Aug 15;17(10):86. doi: 10.1007/s11892-017-0925-9. Review.
Sebastiani G, Valentini M, Grieco GE, Ventriglia G, Nigi L, Mancarella F, Pellegrini S, Martino G, Sordi V, Piemonti L, Dotta F.
MicroRNA expression profiles of human iPSCs differentiation into insulin-producing cells.
Acta Diabetol. 2017 Mar;54(3):265-281. doi: 10.1007/s00592-016-0955-9..
Sordi V, Pellegrini S, Krampera M, Marchetti P, Pessina A, Ciardelli G, Fadini G, Pintus C, Pantè G, Piemonti L.
Stem cells to restore insulin production and cure diabetes.
Nutr Metab Cardiovasc Dis. 2017 Jul;27(7):583-600. doi: 10.1016/j.numecd.2017.02.004. Review.
Sordi V, Pellegrini S, Piemonti L.
Immunological Issues After Stem Cell-Based β Cell Replacement.
Curr Diab Rep. 2017 Sep;17(9):68. doi: 10.1007/s11892-017-0901-4. Review.
van der Torren CR, Zaldumbide A, Duinkerken G, Brand-Schaaf SH, Peakman M, Stangé G, Martinson L, Kroon E, Brandon EP, Pipeleers D, Roep BO.
Immunogenicity of human embryonic stem cell-derived beta cells.
Diabetologia. 2017 Jan;60(1):126-133. doi:10.1007/s00125-016-4125-y
Publications 2016
Assefa Z, Akbib S, Lavens A, Stangé G, Ling Z, Hellemans KH, Pipeleers D.
Direct effect of glucocorticoids on glucose-activated adult rat β-cells increases their cell number and their functional mass for transplantation.
Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E698-E705. doi: 10.1152/ajpendo.00070.2016.
Demeester S, Balke EM, Van der Auwera BJ, Gillard P, Hilbrands R, Lee D, Van de Velde U, Ling Z, Roep BO, Pipeleers DG, Gorus FK, Keymeulen B.
HLA-A*24 Carrier Status and Autoantibody Surges Posttransplantation Associate With Poor Functional Outcome in Recipients of an Islet Allograft.
Diabetes Care. 2016 Jun;39(6):1060-4. doi: 10.2337/dc15-2768.
Pellegrini S, Cantarelli E, Sordi V, Nano R, Piemonti L.
The state of the art of islet transplantation and cell therapy in type 1 diabetes.
Acta Diabetol. 2016 Oct;53(5):683-91. doi: 10.1007/s00592-016-0847-z.
Pipeleers D, Robert T, De Mesmaeker I, Ling Z.
Concise Review: Markers for Assessing Human Stem Cell-Derived Implants as β-Cell Replacement in Type 1 Diabetes.
Stem Cells Transl Med. 2016 Oct;5(10):1338-1344. Epub 2016 Jul 5. doi: 10.5966/sctm.2015-0187. Review.
Szot GL, Yadav M, Lang J, Kroon E, Kerr J, Kadoya K, Brandon EP, Baetge EE, Bour-Jordan H, Bluestone JA.
Tolerance induction and reversal of diabetes in mice transplanted with human embryonic stem cell-derived pancreatic endoderm.
Cell Stem Cell. 2015 Feb 5;16(2):148-57. doi: 10.1016/j.stem.2014.12.001.
Van Dalem A, Demeester S, Balti EV, Keymeulen B, Gillard P, Lapauw B, De Block C, Abrams P, Weber E, Vermeulen I, De Pauw P, Pipeleers D, Weets I, Gorus FK; Belgian Diabetes Registry.
Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio.
PLoS One. 2016 Dec 1;11(12):e0166702. doi: 10.1371/journal.pone.0166702.
van der Torren CR, Verrijn Stuart AA, Lee D, Meerding J, van de Velde U, Pipeleers D, Gillard P, Keymeulen B, de Jager W, Roep BO.
Serum Cytokines as Biomarkers in Islet Cell Transplantation for Type 1 Diabetes.
PLoS One. 2016 Jan 11;11(1):e0146649. doi: 10.1371/journal.pone.0146649